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ABSTRACT Introduction Based on the representative data reflecting the level of physical development and athletic quality, such as the "National Physical Health Test for Students", it is shown that the physical health status of adolescents and children in China is decreasing annually, and the trend of obesity is gradually increasing. Objective Analyze and study the effect of training on the physical fitness of obese children aged 12 to 14 through school soccer training. Methods The effect of school soccer training on the health and physical fitness of obese children aged 12-14 years was studied, and conclusions were drawn by the literature method, experimental method, mathematical statistical method, and logical analysis method. Forty-eight screened obese children were randomly assigned to the experimental and control groups, 24 in each group. The experimental group underwent 12 weeks of soccer training, and the control group underwent 12 weeks of no training control. The subjects' body composition and flexibility quality indices were measured post-intervention. Results The visceral fat index, body fat rate, and muscle rate of boys and girls progressed expressively, with a significant difference (P <0.05). Muscle weight is also known as lean body weight, with an expressive increase in muscle tone. In comparison, the increase in fat weight and muscle ratio in boys was expressively higher than in girls. Conclusion Regular long-term school soccer training can increase mobility in obese children, increase physical flexibility, and help promote physical health and prevent injury. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.
RESUMO Introdução Com base nos dados representativos que refletem o nível de desenvolvimento físico e qualidade atlética, como o "Teste Nacional de Saúde Física para Estudantes", é demonstrado que o estado de saúde física de adolescentes e crianças na China está diminuindo anualmente, e que a tendência de obesidade está aumentando gradualmente. Objetivo Analisar e estudar o efeito do treinamento na aptidão física de crianças obesas entre 12 a 14 anos de idade através do treinamento de futebol escolar. Métodos O efeito do treinamento de futebol escolar sobre a saúde e a aptidão física de crianças obesas de 12-14 anos de idade foi estudado, e as conclusões foram tiradas pelo método da bibliografia, método experimental, método estatístico matemático e método de análise lógica. Quarenta e oito crianças obesas submetidas a triagem foram designadas aleatoriamente aos grupos experimentais e de controle, 24 em cada grupo. O grupo experimental passou por 12 semanas de treinamento de futebol e o grupo de controle passou por 12 semanas sem controle de treinamento. A composição corporal e os índices de qualidade da flexibilidade dos sujeitos foram medidos antes e depois da intervenção. Resultados Resultados: O índice de gordura visceral, a taxa de gordura corporal e a taxa muscular de meninos e meninas progrediu expressivamente, com diferença significativa (P <0,05). O peso de musculatura também é conhecido como peso corporal magro, com um aumento expressivo do tônus muscular. Em comparação, o aumento do peso de gordura e da taxa muscular nos meninos foi expressivamente maior do que o encontrado nas meninas. Conclusão O treinamento regular de futebol escolar de longo prazo pode aumentar a mobilidade das crianças obesas, aumentar a flexibilidade física e ajudar a promover a saúde física além de prevenir lesões. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.
RESUMEN Introducción A partir de los datos representativos que reflejan el nivel de desarrollo físico y la calidad atlética, como la "Prueba Nacional de Salud Física para Estudiantes", se demuestra que el estado de salud física de los adolescentes y niños en China disminuye anualmente, y la tendencia de la obesidad aumenta gradualmente. Objetivo Analizar y estudiar el efecto del entrenamiento sobre la forma física de niños obesos de entre 12 y 14 años mediante el entrenamiento de fútbol escolar. Métodos Se estudió el efecto del entrenamiento de fútbol escolar en la salud y la forma física de niños obesos de 12 a 14 años, y se extrajeron conclusiones mediante el método bibliográfico, el método experimental, el método estadístico matemático y el método de análisis lógico. Cuarenta y ocho niños obesos examinados fueron asignados aleatoriamente a los grupos experimental y de control, 24 en cada grupo. El grupo experimental se sometió a 12 semanas de entrenamiento futbolístico y el grupo de control, a 12 semanas sin entrenamiento. Se midieron la composición corporal y los índices de calidad de la flexibilidad de los sujetos antes y después de la intervención. Resultados El índice de grasa visceral, el índice de grasa corporal y el índice muscular de niños y niñas progresaron expresivamente con diferencias significativas (P <0,05). El peso muscular también se conoce como peso corporal magro, con un aumento expresivo del tono muscular. En comparación, el aumento del peso graso y de la tasa muscular en los chicos fue expresivamente superior al observado en las chicas. Conclusión El entrenamiento regular de fútbol escolar a largo plazo puede aumentar la movilidad en niños obesos, incrementar la flexibilidad física y ayudar a promover la salud física, además de prevenir lesiones. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.
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Objective@#To explore the association between adolescent peer bullying, life satisfaction and self-harm, so as to provide intervention support for the prevention of adolescent self-harm behaviors.@*Methods@#In October 2022, 5 724 junior high school students from Xuancheng, Hefei, Huaibei in Anhui Province were selected by multistage stratified random cluster sampling, and a self-administered adolescent mental health behavior questionnaire was used to conduct the survey.@*Results@#The detection rate of peer bullying among adolescents was 30.0%, and the detection rates of the five self-harm behaviors including highly lethal self-harm, less lethal self-harm with visible tissue damage, self-harm without visible tissue damage, self-harm with latency damage, and psychological self-harm were 10.2%, 25.8%, 35.5%, 20.8% and 28.2%, respectively. Logistic regression model results showed a positive association between exposure to peer bullying and the five self-harmful behaviors ( OR =2.52-3.21, P <0.01), and a negative association between life satisfaction and the five self-harmful behaviors ( OR =0.19-0.33, P <0.01). Adolescent life satisfaction had a moderating effect between exposure to peer bullying and highly lethal self-harm, less lethal self-harm with visible tissue damage, self-harm without visible tissue damage, and self-harm with latency damage ( OR=1.53, 1.42, 1.30, 1.39, P <0.05), and no moderating effect between exposure to peer bullying and psychological self-harm ( P >0.05).@*Conclusion@#Peer bullying among adolescents may increase the risk of self-harm behavior. Improvement of life satisfaction can effectively mitigate the negative effects of peer bullying on adolescent self-harm.
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Objective@#To investigate the prevalence of witnessing domestic violence,and to explore the relationship between witness domestic violence in childhood and college students’ injury and violence behaviors.@*Methods@#In October 2018, self-made questionnaire on “Health and Risky Behaviors among University Students in Anhui Province” was conducted among 4 034 college students from 4 universities in Hefei. Multivariate Logistic regression models (control of confounding factors) were used to explore the impact of childhood witnessing domestic violence on college students’ injury and violence.@*Results@#Among 4 034 college students,the prevalence of witnessing domestic emotional violence,mild physical violence and severe physical violence in childhood was 27.6%,22.4%,10.7%,respectively. Univariate analysis showed that students with experiences of witness domestic emotional violence,mild physical violence and severe physical violence had higher rates of self-injury,physical,emotional,and sexual violence compared to those without domestic violence witness(P<0.05). Multivariate Logistic regression analysis showed that witnessing domestic severe physical violence,emotional violence in childhood associated positively with self-harm (OR=1.53,95%CI=1.05-2.23; OR=2.15,95%CI=1.51-3.04) and emotional violence (OR=1.65,95%CI=1.16-2.35; OR=2.57,95%CI=1.87-3.53). Witnessing domestic severe physical violence showed positive association with physical violence (OR=4.99,95%CI=2.58-9.62) and sexual violence (OR=8.68,95%CI=3.30-22.81) among college students (P<0.05).@*Conclusion@#The experiences of witness domestic violence can increases the risk of college student’s injury and violence behaviors,especially witness domestic severe physical violence.
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A simple, rapid and sensitive method based on an ultra-performance liquid chromatography–tandem mass spectrometry(UPLC–MS/MS)has been developed and validated for the determination of pimavanserin in rat plasma.The analyte was extracted by protein precipitation with methanol and separated on an ACQUITY BEH C18column(100 mm×2.1 mm,1.7μm;Waters,USA),with an isocratic elution of acetonitrile-water containing 10 mM ammonium acetate (70:30, v/v), at a flow rate of 0.2 mL/min for 2.5 min. The analyte and clarithromycin (the internal standard) were detected and quantified in positive ion mode using multiple reaction monitoring transitions at m/z 428.2 → 223.0 for pimavanserin and m/z 748.5 → 589.5 for clarithromycin. Relative coefficient (r) for the calibration curve was more than 0.9980. The intra-day and inter-day precisions(relative standard deviation,RSD%)were less than 13.3% and 10.5%,respectively,and the accuracy(relative error,RE%)was within ± 11.5%.The analytical method was successfully applied to a routine pharmacokinetic study of pimavanserin in rats after oral administration at the dose of 10 mg/kg.